Trump budget would force tough choices in disease research

http://abcnews.go.com/Technology/wireStory/trump-budget-force-tough-choices-disease-research-46183046

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What goes on the chopping block: Research into cancer or Alzheimer’s? A Zika vaccine or a treatment for superbugs?

Health groups say President Donald Trump’s proposal to slash funds for the nation’s engine of biomedical research would be devastating for patients with all kinds of diseases — and for jobs.

“It is possible that the next cure for some cancer is sitting there waiting to be discovered, and it won’t get to the table,” said Dr. Georges Benjamin, executive director of the American Public Health Association.

In his budget blueprint Thursday, Trump called for a cut of $5.8 billion from the National Institutes of Health. That’s a staggering 18 percent drop for the $32 billion agency that funds much of the nation’s research into what causes different diseases and what it will take to treat them.

It comes despite Trump recently telling Congress about the need to find “cures to the illnesses that have always plagued us.”

“All of us woke up this morning in a state of shock about this number,” said Dr. Blase Polite, a cancer specialist at the University of Chicago who chairs the American Society for Clinical Oncology’s government relations committee.

Trump’s proposal would roll back NIH’s 2018 budget to about what it was in 2003. The president called for a “major reorganization” of NIH to stress the “highest priority research,” but only specifically targeted for elimination the $69 million Fogarty International Center that focuses on global health and has played a big role in HIV research abroad.

Drops in deaths from cancer and heart disease, breakthroughs in genetics, and new ways to treat and prevent HIV and other infectious diseases all are credited to decades of NIH-funded basic research.

 

12 superbugs that pose the greatest danger to human health

http://www.fiercehealthcare.com/population-health/who-releases-list-12-priority-pathogens-to-encourage-drug-development?utm_medium=nl&utm_source=internal&mrkid=959610&mkt_tok=eyJpIjoiWkRjeU1tTTFPVEUyTjJaaCIsInQiOiJBNGU4aWlDQkpcL3l6eURqQUMyR2w3aVFtNStxVzBraUpQcTVOamQ4SVNEVUNDeXFQQ1RDWG5qdmptMjI4VWpiVTdHUDltN0ZTMG5ObWlHOWl0cXRmVEpjQ0h2bFU1NXJKM2YzaHBrcnc2VlVJVkoyTHJrQjBndGI5b3BGWmdJV1oifQ%3D%3D

Bacteria

The World Health Organization has released a list of 12 antibiotic-resistant superbugs that pose the greatest danger to human health.

The purpose of the list of “priority pathogens,” according to WHO, is to promote continued research and development of drugs that can be used to treat patients with these resistant infections.

The agency has divided the list according to the urgent need for new antibiotics. The bacteria considered the most critical pose a particular threat to hospitalized patients who may require blood catheters or ventilators. These bacteria, which can cause severe and deadly infections, such as bloodstream infections and pneumonia, are also resistant to drugs designed as a last line of defense for patients.

“This list is a new tool to ensure R&D responds to urgent public health needs,” Marie-Paule Kieny, Ph.D., assistant director-general for health systems and innovation at the WHO, said in an announcement. “Antibiotic resistance is growing, and we are fast running out of treatment options. If we leave it to market forces alone, the new antibiotics we most urgently need are not going to be developed in time.”

Three bacteria resistant to carbapenem, an antibiotic that often treats bacteria that are resistant to other drugs, are listed as critical. Six bacteria are ranked as high-priority and the final three are listed as medium-priority. Bacteria listed as high- or medium-priority are increasingly becoming resistant to different antibiotics and are producing hard-to-treat strains of common conditions, such as gonorrhea and salmonella.

One of the three critical bacteria, carbapenem-resistant Enterobacteriaceae, or CRE, resulted in the death of a Nevada woman last year, and estimates suggest the infection may be more widespread than previously thought.

Global health experts have increasingly warned that superbugs are poised to be a significant threat to patient health. In the next decades, drug-resistant infections could kill more people than cancer. Providers can do their part by focusing on antibiotic stewardship. National healthcare organizations, including the Centers for Medicare & Medicaid Services, have offered guidelines.

Here is the complete list compiled by WHO: