Deadly Superbug Linked To Four Deaths In The U.S.

Deadly Superbug Linked To Four Deaths In The U.S.

Candida auris (C. auris) is a serious and sometimes fatal fungal infection that is emerging globally. (Courtesy of the Centers for Disease Control and Prevention)

A deadly new drug-resistant fungus has been linked to the deaths of four hospital patients in the U.S., according to a report released Friday from the Centers for Disease Control and Prevention.

The fungus, called Candida auris, preys on the sickest patients and can spread in hospitals. Although doctors have been concerned about the spread of antibiotic-resistant bugs for many years, this fungus is relatively new on the world scene. It was first identified in Japan in 2009 and has since spread around the globe, emerging in South America, the Middle East, Africa and Europe, according to the CDC.

The CDC first identified the fungus as a potential threat in 2013, based on a possible case in the U.S., and has been on the lookout for the fungus since June. In its new report, the CDC said the fungus has been detected in a total of 13 patients since May 2013; the agency provided details on the first seven cases, which were reported in New York, Illinois, Maryland and New Jersey.

All of the patients had serious underlying medical conditions, including cancer, and had been hospitalized an average of 18 days when they tested positive for the fungus. Two patients had been treated in the same health care facility and had nearly identical fungal strains. Doctors can’t say for sure if the patients died from the fungus or their underlying health problems.

But health officials say the nation’s hospitals need to be on alert.

“We need to act now to better understand, contain and stop the spread of this drug-resistant fungus,” said Thomas Frieden, director of the CDC. “This is an emerging threat, and we need to protect vulnerable patients and others.”

 

No one knows how many patients are dying from superbug infections in California hospitals

http://www.latimes.com/business/la-fi-torrance-memorial-infections-20161002-snap-story.html?utm_campaign=KHN%3A+First+Edition&utm_source=hs_email&utm_medium=email&utm_content=35220326&_hsenc=p2ANqtz–q48_nyJSgCl8xVrBEwT6GLi1L5uwbL-wFLD1CzsDaqKwJvA7Gvbnan0dOU4uApCaA6Nc4bjRnR-iXNQlJtbH0Z6T0mA&_hsmi=35220326

Sharley McMullen's death certificate says she died from respiratory failure and septic shock caused by her ulcer.

We, the community of physicians, had been watching these patients die and trundling them off to the morgue for years.— Dr. Barry Farr, former president, Society for Healthcare Epidemiology of America

Could It Be Sepsis? C.D.C. Wants More People to Ask

Between one million and three million Americans are given diagnoses of sepsis each year, and 15 percent to 30 percent of them will die, Dr. Frieden said. Sepsis most commonly affects people over 65, but children are also susceptible. According to one estimate, more than 42,000 children develop sepsis in the United States every year, and 4,400 die.

Sepsis develops when the body mounts an overwhelming attack against an infection that can cause inflammation in the entire body. When that happens, the body undergoes a cascade of changes, including blood clots and leaky blood vessels that impede blood flow to organs. Blood pressure drops, multiple organs can fail, the heart is affected, and death can result.

“Your body has an army to fight infections,” said Dr. Jim O’Brien, the chairman of Sepsis Alliance. “With sepsis, your body starts suffering from friendly fire.”

Sepsis appears to be rising. The rate of hospitalizations that listed sepsis as the primary illness more than doubled between 2000 and 2008, according to a 2011 C.D.C. study, which attributed the increase to factors like the aging of the population, a rise in antibiotic resistance and, to some extent, better diagnosis.

Sepsis is a contributing factor in up to half of all hospital deaths, but it’s often not listed as the cause of death because it often develops as a complication of another serious underlying disease like cancer. So although death certificates list sepsis as a cause in 146,000 to 159,000 deaths a year, a recent report estimated that it could play a role in as many as 381,000.

Yet advocacy organizations say many Americans have never heard of sepsis and don’t know the signs and symptoms.

‘Superbug’ scourge spreads as U.S. fails to track rising human toll

http://www.reuters.com/investigates/special-report/usa-uncounted-surveillance/

Fifteen years after the U.S. declared drug-resistant infections to be a grave threat, the crisis is only worsening, a Reuters investigation finds, as government agencies remain unwilling or unable to impose reporting requirements on a healthcare industry that often hides the problem.

http://www.healthleadersmedia.com/quality/hidden-toll-drug-resistant-superbugs-0?spMailingID=9540993&spUserID=MTMyMzQyMDQxMTkyS0&spJobID=1001565259&spReportId=MTAwMTU2NTI1OQS2#

 

The Ultimate Battle Against MRSA

http://www.wsj.com/articles/the-ultimate-battle-against-mrsa-1473699288

An electron micrograph image of Methicillin-resistant Staphylococcus aureus, or MRSA (the purple spheres).

Hospitals give ICU patients germ-killing baths and antibiotic nose ointment upon admission

Superbug resistant to two last-resort antibiotics found in US for first time

Superbug resistant to two last-resort antibiotics found in US for first time

A strain of E. coli resistant to two last-resort antibiotics has for the first time been reported in the United States.

The strain was found in the urine of a man treated at a New Jersey hospital two years ago. It was tested in 2016 as part of a larger analysis of bacteria from the hospital.

For hard-to-treat bacteria infections, the antibiotics colistin and carbapenem are considered the big guns — a last line of defense when nothing else is working. In recent months mcr-1, a gene which confers resistance to colistin, has been found in E. coli from over 30 countries, including bacteria isolated from pigs and people in China and a patient in New York City.

Similarly the gene blaNDM-5 renders the antibiotic carbapenem useless against its bacterial carrier. In 2012, the Centers for Disease Control and Prevention found carbapenem-resistant bacteria in about 4 percent of US hospitals.

Researchers and health officials have feared the joining of these two genes in a single bacterial strain, as it could set the stage for the rise of superbugs that can’t be treated with our current arsenal of drugs. The combination has been detected before in other countries, including Germany, Venezuela, and China, but until now, it has never been seen within the United States.

 

CDC: Most Sepsis Cases Start Outside a Hospital

http://www.medpagetoday.com/CriticalCare/Sepsis/59841?xid=fb_o_

Image result for cdc sepsis awareness campaign

Agency launches new campaign to raise blood infection awareness

Public Health Officials Struggle To Identify Sepsis Before It Becomes Deadly

http://khn.org/news/public-health-officials-struggle-to-identify-sepsis-before-it-becomes-deadly/?utm_campaign=KHN%3A+Daily+Health+Policy+Report&utm_source=hs_email&utm_medium=email&utm_content=33278487&_hsenc=p2ANqtz-_8KIyYxXNIF-21jTIsaT1TCz3UXX37BTMaIxr7_hnAyIOw4I6NhoeCq28LgUM3bjzRgNkA6fCTpslqrXZ1qMCGsCvXeQ&_hsmi=33278487

After Rory Staunton fell at the gym and cut his arm in March of 2012, the 12-year-old became feverish and vomited during the night, complaining of a sharp pain in his leg. When his parents called his pediatrician the next day, she wasn’t worried. She said there was a stomach virus going around New York City, and his leg pain was likely due to his fall.

However, she advised his parents, Orlaith and Ciaran Staunton, to take the youngster to the emergency department because he might be dehydrated. There hospital workers did some blood work, gave him fluids and sent him home.

The next day Rory’s pain and fever were worse. His skin was mottled and the tip of his nose turned blue. The Stauntons raced back to the hospital, where he was admitted to intensive care. The diagnosis: septic shock. Rory was fighting a system-wide infection that was turning his skin black and shutting down his organs. On Sunday, four days after he dove for the ball in gym class, Rory died.

“It was frightening to think that something could kill my son so fast and it would be something that I had never heard of,” said Orlaith Staunton.

She’s not alone. Sepsis kills more than 250,000 people every year. People at highest risk are those with weakened immune systems, the very young and elderly, patients with chronic diseases such as diabetes, cancer or kidney disease and those with illnesses such as pneumonia or who use catheters that can cause infections. But it can strike anyone, even a healthy child like Rory.

Sepsis is a body’s overwhelming response to infection. It typically occurs when germs from an infection get into the bloodstream and spread throughout the body. To fight the infection, the body mounts an immune response that may trigger inflammation that damages tissues and interferes with blood flow. That can lead to a drop in blood pressure, potentially causing organ failure and death.

Where Lead Lurks And Why Even Small Amounts Matter

http://www.npr.org/sections/health-shots/2016/08/12/483079525/where-lead-lurks-and-why-even-small-amounts-matter?utm_campaign=KHN%3A+Daily+Health+Policy+Report&utm_source=hs_email&utm_medium=email&utm_content=32858954&_hsenc=p2ANqtz-8kDCnnjDbfp4JvZ95fZBYFg0rvQnr0k1mC0p1B7O4jguEVJHjhzW0BsVUUUTFVZ8CkCycZO56aYhcnG_R04U8iDQ-JsA&_hsmi=32858954

Katherine Du for NPR

When There’s Lead Underground

When there is a problem with lead in drinking water, service lines are the most likely culprit. Service lines are like tiny straws that carry water from a utility’s water main, usually running below the street, to each building.

In older cities, many of them in the Midwest and Northeast, these service lines can be made of pure lead.

Wherever lead service lines are in place, there is a risk of water contamination. The toxic metal can leach into the water whenever something jostles the pipes, like nearby construction, a heavy truck coming down the road or when the water just sits still for too long.

Civil engineer Marc Edwards, the Virginia Tech professor who helped document the lead problems with water in Flint, calls lead service lines “ticking time bombs.”

Aetna is notifying some doctors about their drug-dispensing habits

https://www.washingtonpost.com/news/to-your-health/wp/2016/08/03/aetna-is-notifying-some-doctors-about-their-drug-dispensing-habits/