A ‘slow catastrophe’ unfolds as the golden age of antibiotics comes to an end

http://www.latimes.com/science/sciencenow/la-sci-antibiotic-resistance-20160711-snap-story.html

Rosslyn Maybank

In early April, experts at a military lab outside Washington intensified their search for evidence that a dangerous new biological threat had penetrated the nation’s borders.

They didn’t have to hunt long before they found it.

On May 18, a team working at the Walter Reed Army Institute of Research here had its first look at a sample of the bacterium Escherichia coli, taken from a 49-year-old woman in Pennsylvania. She had a urinary tract infection with a disconcerting knack for surviving the assaults of antibiotic medications. Her sample was one of six from across the country delivered to the lab of microbiologist Patrick McGann.

Within hours, a preliminary analysis deepened concern at the lab. Over the next several days, more sophisticated genetic sleuthing confirmed McGann’s worst fears.

There, in the bacterium’s DNA, was a gene dubbed mcr-1. Its presence made the pathogen impervious to the venerable antibiotic colistin.

PREPARING FOR PANDEMICS

http://paidpost.nytimes.com/gates-foundation/preparing-for-pandemics.html?WT.mc_id=2016-May-NYTNative_article-GatesPandemic-0520-0729&WT.mc_ev=click?action=click&module=Marginalia&region=Marginalia&pgtype=article&version=PaidPostDriver

During the 1918 Spanish flu pandemic, as many as 100 million people died — up to 5 percent of the world’s population. If a similar outbreak were to happen today, the death toll could reach 360 million, despite the availability of vaccines as well as modern antiviral and antibacterial drugs. The economic impact would also be devastating, resulting in a $3 trillion economic loss, or nearly 5 percent of global GDP.