Superbug resistant to two last-resort antibiotics found in US for first time

A strain of E. coli resistant to two last-resort antibiotics has for the first time been reported in the United States.

The strain was found in the urine of a man treated at a New Jersey hospital two years ago. It was tested in 2016 as part of a larger analysis of bacteria from the hospital.

For hard-to-treat bacteria infections, the antibiotics colistin and carbapenem are considered the big guns — a last line of defense when nothing else is working. In recent months mcr-1, a gene which confers resistance to colistin, has been found in E. coli from over 30 countries, including bacteria isolated from pigs and people in China and a patient in New York City.

Similarly the gene blaNDM-5 renders the antibiotic carbapenem useless against its bacterial carrier. In 2012, the Centers for Disease Control and Prevention found carbapenem-resistant bacteria in about 4 percent of US hospitals.

Researchers and health officials have feared the joining of these two genes in a single bacterial strain, as it could set the stage for the rise of superbugs that can’t be treated with our current arsenal of drugs. The combination has been detected before in other countries, including Germany, Venezuela, and China, but until now, it has never been seen within the United States.