12 superbugs that pose the greatest danger to human health

http://www.fiercehealthcare.com/population-health/who-releases-list-12-priority-pathogens-to-encourage-drug-development?utm_medium=nl&utm_source=internal&mrkid=959610&mkt_tok=eyJpIjoiWkRjeU1tTTFPVEUyTjJaaCIsInQiOiJBNGU4aWlDQkpcL3l6eURqQUMyR2w3aVFtNStxVzBraUpQcTVOamQ4SVNEVUNDeXFQQ1RDWG5qdmptMjI4VWpiVTdHUDltN0ZTMG5ObWlHOWl0cXRmVEpjQ0h2bFU1NXJKM2YzaHBrcnc2VlVJVkoyTHJrQjBndGI5b3BGWmdJV1oifQ%3D%3D

Bacteria

The World Health Organization has released a list of 12 antibiotic-resistant superbugs that pose the greatest danger to human health.

The purpose of the list of “priority pathogens,” according to WHO, is to promote continued research and development of drugs that can be used to treat patients with these resistant infections.

The agency has divided the list according to the urgent need for new antibiotics. The bacteria considered the most critical pose a particular threat to hospitalized patients who may require blood catheters or ventilators. These bacteria, which can cause severe and deadly infections, such as bloodstream infections and pneumonia, are also resistant to drugs designed as a last line of defense for patients.

“This list is a new tool to ensure R&D responds to urgent public health needs,” Marie-Paule Kieny, Ph.D., assistant director-general for health systems and innovation at the WHO, said in an announcement. “Antibiotic resistance is growing, and we are fast running out of treatment options. If we leave it to market forces alone, the new antibiotics we most urgently need are not going to be developed in time.”

Three bacteria resistant to carbapenem, an antibiotic that often treats bacteria that are resistant to other drugs, are listed as critical. Six bacteria are ranked as high-priority and the final three are listed as medium-priority. Bacteria listed as high- or medium-priority are increasingly becoming resistant to different antibiotics and are producing hard-to-treat strains of common conditions, such as gonorrhea and salmonella.

One of the three critical bacteria, carbapenem-resistant Enterobacteriaceae, or CRE, resulted in the death of a Nevada woman last year, and estimates suggest the infection may be more widespread than previously thought.

Global health experts have increasingly warned that superbugs are poised to be a significant threat to patient health. In the next decades, drug-resistant infections could kill more people than cancer. Providers can do their part by focusing on antibiotic stewardship. National healthcare organizations, including the Centers for Medicare & Medicaid Services, have offered guidelines.

Here is the complete list compiled by WHO:

Superbug infection kills patient in Reno

http://www.healthcarefinancenews.com/news/superbug-infection-kills-patient-reno

A superbug infection resistant to all 27 available antibiotics killed a woman in Reno, Nevada, the Centers for Disease Control and Prevention reported Friday, in issuing a precaution to hospitals nationwide.

While this superbug case was rare, sepsis blood infections reportedly kill an estimated 258,000 Americans each year.

Medical experts have been warning for years of the dangers of overprescribing antibiotics because of the potential for antibiotic-resistant superbugs.

The female patient who died this September from the superbug infection was a Washoe County, Nevada resident in her 70s who arrived in the United States in early August 2016 after an extended visit to India, the CDC said.

On August 18, she was admitted to an acute care hospital with a primary diagnosis of an infection called systemic inflammatory response syndrome, which likely resulted from an infected right hip.

A week after she was admitted, the hospital notified the Washoe County Health District in Nevada that the patient had a bacterial infection of carbapenem-resistant Enterobacteriaceae, called CRE.

 

No one knows how many patients are dying from superbug infections in California hospitals

http://www.latimes.com/business/la-fi-torrance-memorial-infections-20161002-snap-story.html?utm_campaign=KHN%3A+First+Edition&utm_source=hs_email&utm_medium=email&utm_content=35220326&_hsenc=p2ANqtz–q48_nyJSgCl8xVrBEwT6GLi1L5uwbL-wFLD1CzsDaqKwJvA7Gvbnan0dOU4uApCaA6Nc4bjRnR-iXNQlJtbH0Z6T0mA&_hsmi=35220326

Sharley McMullen's death certificate says she died from respiratory failure and septic shock caused by her ulcer.

We, the community of physicians, had been watching these patients die and trundling them off to the morgue for years.— Dr. Barry Farr, former president, Society for Healthcare Epidemiology of America

Hospitals work to ensure high-risk patients are ready for surgeries

http://www.fiercehealthcare.com/healthcare/hospitals-work-to-ensure-high-risk-patients-are-ready-for-surgeries?mkt_tok=eyJpIjoiTVdZNE9UbGtZemxtTXpBMCIsInQiOiJVS01rMXhPNVNhS1c0V2JKaE53TSthTHg0dWFnaXVtcUtXeEZlK0VqQTk3SFBNTG01aEJpVVN0aFhqRDZ5cmFGYitGUmtrZHV0K0JGMHBcL2twN2RBeUpSSk5MaW5vS0NcL25JQTk3T2FFTUhrPSJ9&mrkid=959610&utm_medium=nl&utm_source=internal

As healthcare becomes increasingly value-based, surgical outcomes are more important than ever, leading many providers to assess patients’ fitness for elective procedures.

Increasingly, providers make an effort to learn more about patients’ health before operations such as hip and knee replacements, according to The Wall Street Journal, looking for evidence of dangers of infection and other complications. Patients with chronic conditions or lifestyles that put them at higher risk may be directed to “pre-habilitation” programs to increase the odds that their procedures go off without a hitch. These initiatives can involve medical treatments or simply improved diet and exercise, according to the article.

This approach builds on strategies surgeons have employed for years, including advising patients to quit smoking or get in better shape ahead of a procedure, but the range of risks they focus on has broadened considerably to encompass everything from sleep disorders to mental illness, according to the article.

“In health care, we often bring patients into surgery without fully addressing their chronic medical conditions,” Solomon Aronson, M.D., executive vice chair in the anesthesiology department at Duke University School of Medicine in Durham, North Carolina, told the WSJ, and when patients are healthier pre-surgery, “we can significantly diminish the risk of complications.”

For example, Duke Health’s “Poet” (Peri-Operative Enhancement Team) program has focused its efforts on patients with anemia, malnourishment, poor tolerance for exercise, complex pain disorders and diabetes. The fixes the provider offers range from pre-operative iron infusions for anemic patients to a protein shake regimen for older, malnourished patients. In the cases of patients who need such fixes as weight loss or blood sugar control, the Duke team employs longer-term regimens as well.

 

Big-name hospitals often fail to prevent C. diff infections

http://www.fiercehealthcare.com/hospitals/report-c-diff-infections-continue-to-be-a-struggle-for-big-name-medical-centers?utm_medium=nl&utm_source=internal&mrkid=959610&mkt_tok=eyJpIjoiTVdZNE9UbGtZemxtTXpBMCIsInQiOiJVS01rMXhPNVNhS1c0V2JKaE53TSthTHg0dWFnaXVtcUtXeEZlK0VqQTk3SFBNTG01aEJpVVN0aFhqRDZ5cmFGYitGUmtrZHV0K0JGMHBcL2twN2RBeUpSSk5MaW5vS0NcL25JQTk3T2FFTUhrPSJ9

MicroscopeMicroscope

Some of the most well-known hospitals in the nation rank among the worst in preventing deadly Clostridium difficile infections, according to a new Consumer Reports analysis.

The publication analyzed C. diff infections at hospitals across the country, based on data reported to the Centers for Disease Control and Prevention between 2014 and 2015. It found well-known teaching hospitals like the Cleveland Clinic, Baylor University Medical Center in Dallas, Brigham and Women’s Hospital in Boston and Cedars-Sinai Medical Center in Los Angeles had the lowest or second-lowest ranking, indicators that these hospitals fall short against the national benchmark to control such infections.

“Teaching hospitals are supposed to be places where we identify the best practices and put them to work,” Lisa McGiffert, director of Consumer Reports‘ Safe Patient Project, said in an announcement of the findings. “But even they seem to be struggling against this infection.”

The report analyzed data from more than 3,100 U.S. hospitals and found that more than a third received a low score for C. diff infection control.

Only two large teaching hospitals, Mount Sinai Medical Center in Miami Beach, Florida and Maimonides Medical Center in Brooklyn, New York, earned top marks from Consumer Reportson controlling C. diff.

Could It Be Sepsis? C.D.C. Wants More People to Ask

Between one million and three million Americans are given diagnoses of sepsis each year, and 15 percent to 30 percent of them will die, Dr. Frieden said. Sepsis most commonly affects people over 65, but children are also susceptible. According to one estimate, more than 42,000 children develop sepsis in the United States every year, and 4,400 die.

Sepsis develops when the body mounts an overwhelming attack against an infection that can cause inflammation in the entire body. When that happens, the body undergoes a cascade of changes, including blood clots and leaky blood vessels that impede blood flow to organs. Blood pressure drops, multiple organs can fail, the heart is affected, and death can result.

“Your body has an army to fight infections,” said Dr. Jim O’Brien, the chairman of Sepsis Alliance. “With sepsis, your body starts suffering from friendly fire.”

Sepsis appears to be rising. The rate of hospitalizations that listed sepsis as the primary illness more than doubled between 2000 and 2008, according to a 2011 C.D.C. study, which attributed the increase to factors like the aging of the population, a rise in antibiotic resistance and, to some extent, better diagnosis.

Sepsis is a contributing factor in up to half of all hospital deaths, but it’s often not listed as the cause of death because it often develops as a complication of another serious underlying disease like cancer. So although death certificates list sepsis as a cause in 146,000 to 159,000 deaths a year, a recent report estimated that it could play a role in as many as 381,000.

Yet advocacy organizations say many Americans have never heard of sepsis and don’t know the signs and symptoms.

The Ultimate Battle Against MRSA

http://www.wsj.com/articles/the-ultimate-battle-against-mrsa-1473699288

An electron micrograph image of Methicillin-resistant Staphylococcus aureus, or MRSA (the purple spheres).

Hospitals give ICU patients germ-killing baths and antibiotic nose ointment upon admission

Pasadena hospital broke the law by not reporting outbreak, health officials say

http://www.latimes.com/business/la-fi-huntington-scopes-20160602-snap-story.html?utm_campaign=CHL%3A+Daily+Edition&utm_source=hs_email&utm_medium=email&utm_content=30236320&_hsenc=p2ANqtz-_lm3ZAqJytoTYRP6IJ–uGS1B69RXQeIf-4x1ap_m-lNBp0yTz31E9RiGgAwb2j7q15n-l_WjlHn2a8eubwO5kihmvWw&_hsmi=30236320

Olympus scope

Pasadena’s Huntington Hospital broke state law by not quickly reporting a suspected deadly outbreak last year, according to a letter by city officials.

The hospital released the letter this week, as well as the results of the city’s investigation into the outbreak caused by dirty scopes, which sickened 16 patients, including 11 who died.

City health officials did not investigate the cause of the patients’ deaths, many of whom were seriously ill. The officials noted in the report that only one patient’s death certificate listed as a cause the dangerous drug-resistant bacteria that contaminated the scopes and sickened the patients.

Superbug threat grows in DC hospitals

http://www.fiercehealthcare.com/story/superbug-threat-grows-dc-hospitals/2016-05-04?utm_medium=nl&utm_source=internal&mrkid=959610&mkt_tok=eyJpIjoiTWpVd1lqSTNZalZsWWpReCIsInQiOiJINE9BNitVSm1VYUR3NFVOZG1YMFFiVFQ2d2lmRGtEZ01NdjVpY0x2bmZUSmxTVFFcL2NcL3FMTmlGaXJqRFhSUHI2Tm1yK0Q1MHU1R3U2OWlGQ3NVYU9uTll2VXMxcEJSdUxlcGlYSjJEV1ZBPSJ9

New report finds prevalence of 5% drug-resistant bacteria in District.

http://www.bizjournals.com/washington/news/2016/05/03/exclusive-first-ever-study-of-superbugs-in-d-c.html